Hippocampal volume and declarative memory function in combat-related PTSD
نویسندگان
چکیده
منابع مشابه
Hippocampal volume and declarative memory function in combat-related PTSD.
The proposition that declarative memory deficits are systematically related to smaller hippocampal volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correlative analysis was extended by including multiple measures of verbal and visual declarative memory and multiple memory-relevant regional brain...
متن کاملHippocampal volume, PTSD, and alcoholism in combat veterans.
Studies imposing rigorous control over lifetime alcohol intake have usually not found smaller hippocampal volumes in persons with posttraumatic stress disorder. Because the majority of negative studies have used adolescent samples, it has been suggested that chronicity is a necessary condition for such findings. To test the hypothesis that a smaller hippocampus in PTSD is unrelated to comorbid ...
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Neurobiological models of posttraumatic stress disorder (PTSD) suggest that altered activity in the medial temporal lobes (MTL) during encoding of traumatic memories contribute to the development and maintenance of the disorder. However, there is little direct evidence in the PTSD literature to support these models. The goal of the present study was to examine MTL activity during trauma encodin...
متن کاملThe role of hippocampal iron concentration and hippocampal volume in age-related differences in memory.
The goal of this study was to examine the relationships between 2 age-sensitive indices of brain integrity--volume and iron concentration--and the associated age differences in memory performance. In 113 healthy adults (age 19-83 years), we measured the volume and estimated iron concentration in the hippocampus (HC), caudate nucleus (Cd), and primary visual cortex (VC) in vivo with T2* relaxati...
متن کاملA Pilot Study of Mifepristone in Combat-Related PTSD
Background. We obtained pilot data to examine the clinical and neuroendocrine effects of short-term mifepristone treatment in male veterans with PTSD. Methods. Eight male veterans with military-related PTSD completed a randomized, double-blind trial of one week of treatment with mifepristone (600 mg/day) or placebo. The primary clinical outcome measures were improvement in PTSD symptoms and dic...
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ژورنال
عنوان ژورنال: Journal of the International Neuropsychological Society
سال: 2009
ISSN: 1355-6177,1469-7661
DOI: 10.1017/s1355617709990476